Let-7b and microRNA-199a inhibit the proliferation of B16F10 melanoma cells
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منابع مشابه
MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling.
Neural stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits increased expression during neural differentiation. However, the role of let-7b in neural stem cell proliferation and differentiation remains unknown. Here we show that...
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MicroRNAs are regulatory factors that play important roles in tumor development, invasion and metastasis. Previously, we showed that miR-199a is abnormally expressed in clinical melanoma specimens and expression was closely associated with clinical features of metastasis. However, the exact molecular mechanisms by which miR-199a-5p influences melanoma invasion and metastasis remains unclear. In...
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545 Acta Endocrinologica (Buc), vol. X, no. 4, p. 545-558, 2014 *Correspondence to: Daniel Boda MD, PhD, “Carol Davila” University of Medicine and Pharmacy Dermatology Research Laboratory, 22-24 Gr. Manolescu, Sector 1, Bucharest, 0111234, Romania, E-mail: [email protected] Abstract Context. Melanoma is the most aggressive skin cancer, with significant morbidity and mortality, and one facto...
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The present study investigated the role of epidermal stem cell-expressed microRNA let-7b in the pathogenesis of hypertrophied anal papillae. Hypertrophied anal papillae were examined for the presence of epidermal stem cells. Epidermal stem cells were identified using flow cytometry and immunofluorescent staining for the cell surface markers, integrin α6 and integrin β1 subunits. Expression leve...
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MicroRNAs (miRNAs) are non-coding RNAs involved in various biological processes by regulating their target genes. Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) inhibits melanoma tumor growth by activating 67-kDa laminin receptor (67LR) signaling. To examine the effect of EGCG on miRNA expression in melanoma cells, we performed miRNA microarray analysis. We showed that EGCG up-reg...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2012
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2012.878